bs-11237R-Biotin [Conjugated Primary Antibody]
TCF12/HEB Polyclonal Antibody, Biotin Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: TCF12/HEB

Immunogen Range: 51-150/682


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6938

Swiss Prot: Q99081

Source: KLH conjugated synthetic peptide derived from human TCF12

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 73


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Sheep
Horse
Rabbit
Zebrafish

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Chen, Qing-biao, et al. "Decreased expression of TCF12 contributes to progression and predicts biochemical recurrence in patients with prostate cancer." Tumor Biology 39.6 (2017): 1010428317703924.Read more>>
  • Mengjin Gao. et al. circHIPK3 regulates proliferation and differentiation of myoblast through the miR\7/TCF12 pathway. 2021 Mar 21Read more>>