bs-1110C
[Life Science]
Co-1686
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 555.55
Formula: C27 H28 F3 N7 O3
CAS Number: 1374640-70-6
InChi Key: HUFOZJXAKZVRNJ-UHFFFAOYSA-N
InChi: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
Smiles: CC(=O)N1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(NC2C=C(C=CC=2)NC(=O)C=C)C(=CN=1)C(F)(F)F
Purity: 98.0
Solubility: DMSO: ‚â• 43 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C27 H28 F3 N7 O3
CAS Number: 1374640-70-6
InChi Key: HUFOZJXAKZVRNJ-UHFFFAOYSA-N
InChi: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
Smiles: CC(=O)N1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(NC2C=C(C=CC=2)NC(=O)C=C)C(=CN=1)C(F)(F)F
Purity: 98.0
Solubility: DMSO: ‚â• 43 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
CO-1686 is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.