DATASHEET
Host:
Rabbit
Target Protein:
kappa Opioid receptor
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
4986
Source:
KLH conjugated synthetic peptide derived from human kappa Opioid receptor
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors.The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.
PRODUCT SPECIFIC PUBLICATIONS
- Xiaofan Xiong. et al. Cell apoptosis in the testis of male rats is elevated by intervention with -endorphin and the mu opioid receptor. REPROD BIOL. 2023 Sep;23:100789Read more>>
VALIDATION IMAGES
A549 cell lysates probed with Anti-kappa Opioid receptor Polyclonal Antibody, Unconjugated (bs-1094R) at 1:300 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 90min in RT.
Lane 1: Mouse Cerebrum tissue lysates; Lane 2: Mouse Cerebellum tissue lysates; Lane 3: Rat Cerebrum tissue lysates; Lane 4: Rat Cerebellum tissue lysates probed with kappa Opioid receptor Polyclonal Antibody, Unconjugated (bs-1094R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.