bs-10900P
[Protein]
Recombinant human GAPDH protein, C-His
DATASHEET
Entrez Gene: 2597
Swiss Prot: P04406
Source: Recombinant human GAPDH protein, C-His protein is expressed in E.coli with C-His. It contains the amino acid sequence of 2-335/335.
Storage Buffer: 0.01M TBS(pH7.4)
Storage: The product should be stored at -70°C or -20°C.
Background:
Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 38kDa subunits.
Size: 100ug,500ug
Applications: ELISA()
Mol. Wt.: 37
Species: Others
For research use only. Not intended for diagnostic or therapeutic use.