DATASHEET
Entrez Gene:
2022
Swiss Prot:
P17813
Source:
Recombinant human CD105 protein, C-His protein is expressed in E.coli with C-His. It contains the amino acid sequence of 26-586/658.
Storage Buffer:
0.01M TBS(pH7.4)
Storage:
The product should be stored at -70°C or -20°C.
Background:
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]