bs-10731R-Cy3

DATASHEET

Host: Rabbit

Target Protein: RRAGA + RRAGB

Immunogen Range: 231-313/313

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 10670

Swiss Prot: Q7L523

Source: KLH conjugated synthetic peptide derived from human RRAGA and RRAGB

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 37

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Sheep
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.