bs-1070C
[Life Science]
CID-2011756
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 396.87
Formula: C22 H21 Cl N2 O3
CAS Number: 638156-11-3
InChi Key: XQJWTJLJEYIUDZ-UHFFFAOYSA-N
InChi: InChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26)
Smiles: O=C(NC1=CC=C(CN2CCOCC2)C=C1)C1=CC=C(O1)C1=CC(Cl)=CC=C1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C22 H21 Cl N2 O3
CAS Number: 638156-11-3
InChi Key: XQJWTJLJEYIUDZ-UHFFFAOYSA-N
InChi: InChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26)
Smiles: O=C(NC1=CC=C(CN2CCOCC2)C=C1)C1=CC=C(O1)C1=CC(Cl)=CC=C1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells. IC50 Value: 10±0.7 uM (cellular inhibition of phospho-Ser916-PKD1 activity) [1] Target: PKD CID 2011756, has pan-PKD inhibitory effects (PKD2 IC50 = 0.6±0.1 uM; PKD3 IC50 = 0.7±0.2 uM) with similar, albeit not identical, potencies which may be expected for an ATP competitive inhibitor. CID 2011756 was the most potent of the inhibitors with a cellular EC50 of 10±0.7 uM (n = 3), an EC50 value comparable to that of our previously described benzoxoloazepinolone.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.