bs-10411R-Cy5 [Conjugated Primary Antibody]
Cyclooxygenase 2 Polyclonal Antibody, Cy5 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Cyclooxygenase 2

Immunogen Range: 301-400/604


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5743

Swiss Prot: P35354

Source: KLH conjugated synthetic peptide derived from human Cyclooxygenase 2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 65


Cross Reactive Species: Human
Mouse
Rat
Sheep

Predicted Cross Reactive Species: Dog
Cow
Pig
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ding L et al. Saponins of sea cucumber attenuate atherosclerosis in ApoE −/− mice via lipid-lowering and anti-inflammatory properties. Journal of Functional Foods,2018 48, 490–497.Read more>>
  • Zheng, Jian, et al. "Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats." Journal of Neurosurgery (2016): 1-9.Read more>>
  • Bi et al. Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice. (2017) Sci.Rep. 7:10001Read more>>
  • Xiao L et al. Dihydrotestosterone synthesis in the sheep corpus luteum and its potential mechanism in luteal regression. J Cell Physiol. 2019 Jan 22. Read more>>
  • Ding L et al. Saponins of sea cucumber attenuate atherosclerosis in ApoE −/− mice via lipid-lowering and anti-inflammatory properties. Journal of Functional Foods,2018 48, 490–497.Read more>>
  • Zubeyir Elmazoglu. et al. TLR4, RAGE, and p\JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox\sensitive phenolic olive compounds: Comparison with ibuprofen. J Tissue Eng Regen M. 2020 Dec;14(12):1841-1857Read more>>
  • Qiu Lei. et al. MiR-526b-3p Inhibits the Resistance of Glioma Cells to Adriamycin by Targeting MAPRE1. J Oncol. 2022;2022:2402212Read more>>
  • Xiao Wang. et al. Salvia miltiorrhiza polysaccharides alleviate florfenicol-induced inflammation and oxidative stress in chick livers by regulating phagosome signaling pathway. ECOTOX ENVIRON SAFE. 2023 Jan;249:114428Read more>>
  • Yahui Dong. et al. Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid. J ETHNOPHARMACOL. 2024 Jan;319:11711Read more>>
  • Xiaoying Wu. et al. Radix Sophorae Flavescentis of Sophora flavescens Aiton inhibits LPS-induced macrophage pro-inflammatory response via regulating CFHR2 expression. J ETHNOPHARMACOL. 2024 Apr;:11821Read more>>
  • Zhen Chen. et al. AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4. EXP CELL RES. 2024 May;:114087Read more>>
  • Liu Han. et al. USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis. N-S ARCH PHARMACOL. 2024 May;:1-1Read more>>
  • Adel Rana. et al. Oxidative stress and NF-KB/iNOS inflammatory pathway as innovative biomarkers for diagnosis of drowning and differentiating it from postmortem submersion in both fresh and saltwater in rats. INT J LEGAL MED. 2024 May;:1-16Read more>>
  • Wenqi Chen. et al. Combined Exposure to High-Cholesterol Diet and PM2.5: Brain Injury and Regulatory Mechanism of HIF-1 in ApoE/ Female Mice. ATMOSPHERE-BASEL. 2024 Aug;15(8):952Read more>>
VALIDATION IMAGES