bs-1040C
[Life Science]
CGK733
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 555.84
Formula: C23 H18 Cl3 F N4 O3 S
CAS Number: 905973-89-9
InChi Key: HLCDNLNLQNYZTK-UHFFFAOYSA-N
InChi: InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
Smiles: [O-][N+](=O)C1C=C(C=CC=1F)NC(=S)NC(NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(Cl)(Cl)Cl
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C23 H18 Cl3 F N4 O3 S
CAS Number: 905973-89-9
InChi Key: HLCDNLNLQNYZTK-UHFFFAOYSA-N
InChi: InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
Smiles: [O-][N+](=O)C1C=C(C=CC=1F)NC(=S)NC(NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(Cl)(Cl)Cl
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
CGK733 is an ATM inhibitor and ATR inhibitor, which significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cells through multinucleation and mitotic catastrophe in HBV-positive HepG2.2.15 cells. These results suggest that CGK733 could potentially reverse the taxol resistance in HBV-positive HCC cells and may suggest a novel strategy to treat HBV-infected HCC patients.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.