bs-1020C
[Life Science]
GNF-2
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 374.32
Formula: C18 H13 F3 N4 O2
CAS Number: 778270-11-4
InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N
InChi: InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
Smiles: NC(=O)C1C=C(C=CC=1)C1=CC(NC2C=CC(=CC=2)OC(F)(F)F)=NC=N1
Purity: 98.0
Solubility: DMSO: ‚â• 45 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C18 H13 F3 N4 O2
CAS Number: 778270-11-4
InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N
InChi: InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
Smiles: NC(=O)C1C=C(C=CC=1)C1=CC(NC2C=CC(=CC=2)OC(F)(F)F)=NC=N1
Purity: 98.0
Solubility: DMSO: ‚â• 45 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. Selective for Bcr-abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.