bs-1014R-PE [Conjugated Primary Antibody]
CD11b/c Polyclonal Antibody, PE Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CD11b, CD11c

Specificity: The immunogen of this product has partial sequence similarity to CD11d and may cross react.

Immunogen Range: 77-180/1152


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3684

Swiss Prot: P11215

Source: KLH conjugated synthetic peptide derived from human CD11b

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 125


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Lee HJ et al. Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid‐derived suppressor cells.Am J Transplant. 2018 Dec;18(12):3029-3037. Read more>>
  • Liu, Tao, et al. "Gr-1+ CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation." Scientific Reports 4 (2014).Read more>>
  • Yu, Keke, et al. "Ethanol Supports Macrophage Recruitment and Reinforces Invasion and Migration of Lewis Lung Carcinoma." Alcoholism: Clinical and Experimental Research 38.10 (2014): 2597-2606.Read more>>
  • Kobayashi, Aya, et al. "AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian Cancer." European Journal of Pharmacology (2015).Read more>>
  • Zhang, Qian-Qian, et al. "CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment." Scientific reports 5 (2015).Read more>>
  • Velázquez, Kandy T., et al. "MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer."American Journal of Physiology-Gastrointestinal and Liver Physiology 310.6 (2016): G347-G358.Read more>>
  • Velázquez, Kandy T., et al. "MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer."American Journal of Physiology-Gastrointestinal and Liver Physiology 310.6 (2016): G347-G358.Read more>>
  • Yamaguchi, Tomoyuki, et al. "Interspecies organogenesis generates autologous functional islets." Nature (2017).Read more>>
  • Xu, Ying, et al. "Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway." Oncotarget8.49 (2017): 86339.Read more>>
  • Zhang et al. Proteus mirabilis inhibits cancer growth and pulmonary metastasis in a mouse breast cancer model. (2017) PLoS.On. 12:e0188960Read more>>
  • Oh et al. Analysis of macrophage phenotype in rejected corneal allografts. (2013) Invest.Ophthalmol.Vis.Sc. 54:7779-84Read more>>
  • Long et al. Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells. (2017) Aging.Di. 8:301-313Read more>>
  • Yamaguchi et al. Suppression of hepatic dysfunction in tenascin‑X‑deficient mice fed a high‑fat diet. (2017) Mol.Med.Rep. 16:4061-4067Read more>>
  • Xu et al. Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway. (2017) Oncotarget. 8:86339-86356Read more>>
  • Tatebayashi K et al. Adipose-derived stem cell therapy inhibits the deterioration of cerebral infarction by altering macrophage kinetics. Brain Res. 2019 Feb 2. pii: S0006-8993(19)30061-7.Read more>>
  • Bronzuoli MR et al. Neuroglia in the autistic brain: evidence from a preclinical model. Mol Autism. 2018 Dec 27;9:66. Read more>>
  • Zhan Q et al. Structural characterization and immunomodulatory activity of a novel acid polysaccharide isolated from the pulp of Rosa laevigata Michx fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.Read more>>
  • Lee HJ et al. Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid‐derived suppressor cells.Am J Transplant. 2018 Dec;18(12):3029-3037. Read more>>
  • Zhixiong Li et al. Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke Mousemodel. Biomed Pharmacother. 2020 Jul;127:110213.Read more>>
  • Qian Liet al. LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells. Front Cell Dev Biol. 2020 Jul 14;8:596.Read more>>
  • Feng Y et al. Long noncoding RNA HOXA-AS2 functions as an oncogene by binding to EZH2 and suppressing LATS2 in acute myeloid leukemia (AML)Cell Death Dis.2020 Dec 2;11(12):1025.Read more>>
  • Ning Ran. et al. MOTS\c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. Embo Mol Med. 2021 Feb;13(2):e12993Read more>>
  • Vittoria Borgonetti. et al. Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain. Pharmacol Res. 2021 Jan;:105431Read more>>
  • ingsheng Yang. et al. Identification of prognostic biomarkers associated with metastasis and immune infiltration in osteosarcoma. Oncol Lett. 2021 Mar;21(3):1-1Read more>>
  • Ying Xu. et al. PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation. Free Radical Bio Med. 2020 Nov;160:871Read more>>
  • Shanshan Hu. et al. A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery. Nat Commun. 2021 Mar;12(1):1-17Read more>>
  • Honggang Chi. et al. Shaoyao Decoction Inhibits Inflammation and Improves Intestinal Barrier Function in Mice With Dextran Sulfate Sodium-Induced Colitis. Front Pharmacol. 2021; 12: 524287Read more>>
  • Yao Li. et al. Overexpression of Toll-like receptor 4 contributes to the internalization and elimination of Escherichia coli in sheep by enhancing caveolae-dependent endocytosis. J Anim Sci Biotechno. 2021 Dec;12(1):1-16Read more>>
  • Yasunori Yoshida. et al. Intravenous Administration of Human Amniotic Mesenchymal Stem Cells in the Subacute Phase of Cerebral Infarction in a Mouse Model Ameliorates Neurological Disturbance by Suppressing Blood Brain Barrier Disruption and Apoptosis via Immunomodulation:. Cell Transplant. 2021;()Read more>>
  • Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359Read more>>
  • Xuejun Dai. et al. Comparison of the differentiation abilities of bone marrow?derived mesenchymal stem cells and adipose?derived mesenchymal stem cells toward nucleus pulposus?like cells in three?dimensional culture. Exp Ther Med. 2021 Sep;22(3):1-9Read more>>
  • Tianying Pan. et al. Autism-Like Behavior in the Offspring of CYP11A1-Overexpressing Pregnant Rats. Front Neurosci-Switz. 2021; 15: 774439Read more>>
  • Meiju Zhang. et al. The role of E2A in ATPR-induced cell differentiation and cycle arrest in acute myeloid leukaemia cells. J Cell Mol Med. 2022 Feb;26(4):1128-1143Read more>>
  • Prasant Kumar Jena. et al. Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline. Cells-Basel. 2022 Jan;11(3):504Read more>>
  • Chengjie Wu. et al. A new method for primary culture of microglia in rats with spinal cord injury. Biochem Bioph Res Co. 2022 Apr;599:63Read more>>
  • Yao Li. et al. Rapid surface display of mRNA antigens by bacteria-derived outer membrane vesicles for a personalized tumor vaccine. 2022 Mar 22Read more>>
  • Xueqin He. et al. Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder. 2022 Mar 13Read more>>
  • Ruijing Zhao. et al. Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury. J Control Release. 2022 May;345:214Read more>>
  • Li, Qiao-Yun. et al. Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury. J NEUROINFLAMM. 2022 Dec;19(1):1-2Read more>>
  • Xuan Li. et al. ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation. BIOMATERIALS. 2022 Aug;287:121683Read more>>
  • Cheng Cao. et al. TREM2 modulates neuroinflammation with elevated IRAK3 expression and plays a neuroprotective role after experimental SAH in rats. NEUROBIOL DIS. 2022 Sep;171:105809Read more>>
  • Xiao Yichen. et al. Galectin-3 Is a Crucial Immunological Disease Marker in Patients with Fungal Keratitis. DIS MARKERS. 2022;2022:138056Read more>>
  • R. Shiokawa. et al. Glibenclamide attenuates brain edema associated with microglia activation after intracerebral hemorrhage. NEUROCHIRURGIE. 2022 AugRead more>>
  • Zhaoqi Zhang. et al. Central gene transcriptional regulatory networks shaping monocyte development in bone marrow.. FRONT IMMUNOL. 2022 Oct;13:1011279-1011279Read more>>
  • Nana Qiao. et al. Synergistic regulation of microglia differentiation by CD93 and integrin 1 in the rat pneumococcal meningitis model. IMMUNOL LETT. 2022 Dec;251-252:63Read more>>
  • Guo, Zhi-chen. et al. Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating the neutrophil chemotaxis in the tumour microenvironment. CANCER IMMUNOL IMMUN. 2022 Dec;:1-17Read more>>
  • Vittoria Borgonetti. et al. Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation. PHYTOTHER RES. 2022 DecRead more>>
  • Vittoria Borgonetti. et al. Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain. PHYTOMEDICINE. 2023 Mar;111:15467Read more>>
  • Jiexia Wen. et al. Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer. CELL IMMUNOL. 2023 Mar;385:104676Read more>>
  • Ruyi Qu. et al. Glucocorticoids improve the balance of M1/M2 macrophage polarization in experimental autoimmune uveitis through the P38MAPK-MEF2C axis. INT IMMUNOPHARMACOL. 2023 Jul;120:110392Read more>>
VALIDATION IMAGES