bs-1009R-Cy5 [Conjugated Primary Antibody]
CXCR1 Polyclonal Antibody, Cy5 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CXCR1

Immunogen Range: 186-280/350


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3577

Swiss Prot: P25024

Source: KLH conjugated synthetic peptide derived from human CXCR1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 40


Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Dog
Cow
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tang, Cui, et al. "High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma." International Journal of Clinical and Experimental Pathology 7.6 (2014): 3213-3223.Read more>>
  • Schneberger, D., et al. "CXCR1/CXCR2 antagonist CXCL8 (3-74) K11R/G31P blocks lung inflammation in swine barn dust-instilled mice." Pulmonary Pharmacology & Therapeutics (2015).Read more>>
  • Zhao, Le, et al. "Role of GPER1, EGFR and CXCR1 in differentiating between malignant follicular thyroid carcinoma and benign follicular thyroid adenoma."International Journal of Clinical and Experimental Pathology 8.9 (2015): 11236-11247.Read more>>
  • Tang et al. High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma. (2014) Int.J.Clin.Exp.Patho. 7:3213-23Read more>>
  • Guangxu Xiao. et al. CXCR1 and its downstream NF-B inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.. FRONT IMMUNOL. 2022 Oct;13:1007341-1007341Read more>>
  • Chengfei Xu. et al. CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats. MOL PAIN. ;()Read more>>
  • Yuan Li. et al. A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration. SMALL. 2023 Jul;:2300578Read more>>
VALIDATION IMAGES