bs-0920R-FITC [Conjugated Primary Antibody]
VCAM1 Polyclonal Antibody, FITC Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: VCAM1

Immunogen Range: 651-739/739


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7412

Swiss Prot: P19320

Source: KLH conjugated synthetic peptide derived from human VCAM-1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 81


Cross Reactive Species: Human
Mouse
Rat
Sheep
Rabbit

Predicted Cross Reactive Species: Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856.Read more>>
  • Tang, Li‐Qin, et al. "The renoprotective effects of berberine and its potential impact on the expression of β‐arrestins and ICAM‐1/VCAM‐1 in streptozocin induced‐diabetic nephropathy rats." Journal of Diabetes (2015).Read more>>
  • Lozhkin, Andrey, et al. "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." Journal of Molecular and Cellular Cardiology (2016).Read more>>
  • Mu, Wei, et al. "Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications." Experimental and therapeutic medicine 10.2 (2015): 423-428.Read more>>
  • Kim, Chae Eun, et al. "Effects of silk fibroin in murine dry eye." Scientific Reports 7 (2017): 44364.Read more>>
  • Bartko, Philipp E., et al. "Effect of Losartan on Mitral Valve Changes After Myocardial Infarction." Journal of the American College of Cardiology 70.10 (2017): 1232-1244.Read more>>
  • Vendrov, Aleksandr E., et al. "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." Journal of the American Heart Association 6.11 (2017): e006775.Read more>>
  • Tang et al. The renoprotective effects of berberine and its potential impact on the expression of β-arrestins and ICAM-1/VCAM-1 in streptozocin induced-diabetic nephropathy rats. (2015) J.Diabetes. Read more>>
  • Belcher et al. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. (2018) PLoS.One. 13:e0196455Read more>>
  • Zhang P et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. (2018) Int J Mol Med. 2018 Sep 19. Read more>>
  • Zhang et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. (2018) Int.J.Mol.Med. 42:3344-3354Read more>>
  • Shim W et al. Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eyetherapeutics. J Control Release. 2019 May 20.Read more>>
  • Park EY et al. Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway. Immunopharmacol Immunotoxicol. 2019 Jun 23:1-8.Read more>>
  • Zhao H et al. miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. J Cell Physiol. 2019 Oct 21.Read more>>
  • Jianting Yao. et al. Low-Intensity Focused Ultrasound-Responsive Ferrite-Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics. 2021 Aug 11Read more>>
  • ohui Xiong. et al. LncRNA8276 primes cellCcell adhesion for regulation of spermatogenesis. ANDROLOGY-US. 2022 SepRead more>>
  • Huan Zhang. et al. Hydrogel coating containing heparin and cyclodextrin/paclitaxel inclusion complex for retrievable vena cava filter towards high biocompatibility and easy removal. INT J BIOL MACROMOL. 2024 Oct;277:134509Read more>>
VALIDATION IMAGES