bs-0828R-BF750 [Conjugated Primary Antibody]
Thrombin receptor Polyclonal Antibody, AbBy Fluor® 750 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Thrombin receptor

Immunogen Range: 251-350/425


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2149

Swiss Prot: P25116

Source: KLH conjugated synthetic peptide derived from human PAR1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Conjugation: AbBy Fluor® 750

Excitation/ Emission: 749nm/775nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 42


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Akaishi T et al. The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways. Biol Pharm Bull. 2020;43(1):138-144.Read more>>
  • Fan, Hai-Xia, et al. "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." OncoTargets and therapy 8 (2015): 1619.Read more>>
  • Acton, David, and Gareth B. Miles. "Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine." PLOS ONE 10.8 (2015): e0134488.Read more>>
  • Shimon, Marina Ben, et al. "Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus." PloS one 12.11 (2017): e0188524.Read more>>
  • Shimon et al. Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus. (2017) PLoS.One. 12:e0188524Read more>>
  • Posthuma JJ et al. Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. (2018) J Vasc Surg. Read more>>
  • Noguchi D et al. Antiapoptotic Effect by PAR-1 Antagonist Protects Mouse Liver Against Ischemia-Reperfusion Injury. J Surg Res. 2019 Oct 22. pii: S0022-4804(19)30689-4. Read more>>
  • Akaishi T et al. The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways. Biol Pharm Bull. 2020;43(1):138-144.Read more>>
  • Kumar M et al. Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y CellsBrain Sci.2020 Dec 10;10(12):959.Read more>>
  • Chao G et al. Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activityBiomarkers.2021 Feb;26(1):38-44.Read more>>
  • Daisuke Noguchi. et al. The impact of dabigatran treatment on sinusoidal protection against hepatic ischemia\reperfusion injury in mice. 2020 Oct 27Read more>>
  • Yingchun Wang. et al. Therapeutic Effects of a Novel Aptamer on Coronaviral Infection-Induced Lung Injury and Systemic Inflammatory Responses. CELLS-BASEL. 2024 Jan;13(5):422Read more>>
VALIDATION IMAGES