bs-0781R [Primary Antibody]
IL-6 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-6

Immunogen Range: 26-50/212


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3569

Swiss Prot: P05231

Source: KLH conjugated synthetic peptide derived from human IL-6

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Size: 100ul

Concentration: 1ug/ul

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 23


Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu, Ping-Zhen, et al. "Electrochemiluminescence immunosensor based on graphene oxide nanosheets/polyaniline nanowires/CdSe quantum dots nanocomposites for ultrasensitive determination of human interleukin-6." Electrochimica Acta (2013).Read more>>
  • Liu, Ping-Zhen, et al. "Electrochemiluminescence immunosensor based on graphene oxide nanosheets/polyaniline nanowires/CdSe quantum dots nanocomposites for ultrasensitive determination of human interleukin-6." Electrochimica Acta (2013).Read more>>
  • Xu, Hong-Wu, et al. "The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients." BMC cancer 13.1 (2013): 247.Read more>>
  • Lozhkin, Andrey, et al. "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." Journal of Molecular and Cellular Cardiology (2016).Read more>>
  • Sun et al. Significance of interstitial tumor-associated macrophages in the progression of lung adenocarcinoma. (2016) Oncol.Let. 12:4467-4476Read more>>
  • Han et al. Electroacupuncture modulated the inflammatory reaction in MCAO rats via inhibiting the TLR4/NF-κB signaling pathway in microglia. (2015) Int.J.Clin.Exp.Patho. 8:11199-205Read more>>
  • Pei et al. Interstitial tumor-associated macrophages combined with tumor-derived colony-stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non-small cell lung cancer. (2014) J.Thorac.Cardiovasc.Surg. 148:1208-1216.e2Read more>>
  • Luo Q et al. Iron Overload Resulting from the Chronic Oral Administration of Ferric Citrate Impairs Intestinal Immune and Barrier in Mice. Biol Trace Elem Res. 2020 May 28.Read more>>
  • Tao Pan. et al. Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL?6/STAT3 signaling pathway. Oncol Rep. 2020 Sep;44(3):1049-1063Read more>>
  • Li, Lu. et al. Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats. BMC Complementary Medicine and Therapies. 2022 Dec;22(1):1-13Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded Human oral mucosa labeled with Anti-IL-6(human) Polyclonal Antibody, Unconjugated (bs-0781R) at 1:200, followed by conjugation to the secondary antibody and DAB staining