bs-0742R-BF647 [Conjugated Primary Antibody]
CDKN1B Polyclonal Antibody, AbBy Fluor® 647 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CDKN1B

Immunogen Range: 101-198/198


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1027

Swiss Prot: P46527

Source: KLH conjugated synthetic peptide derived from human CDKN1B

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Conjugation: AbBy Fluor® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 22


Cross Reactive Species: Human
Mouse
Rat
Chicken
Others

Predicted Cross Reactive Species: Dog
Sheep
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Sun, Yan, et al. "Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway." Theriogenology (2014).Read more>>
  • Gao, LiLi, et al. "Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells." Molecular Medicine 21.1 (2015): 154.Read more>>
  • Akizuki, Risa, et al. "Claudin-5,− 7, and− 18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research (2016).Read more>>
  • Guo, Fangzi, et al. "Endosulfan induces apoptosis by activating the negative regulation pathway of cell cycle and death receptor pathway in spermatogenic cells." Toxicology Research (2017).Read more>>
  • Abdalla, BA., et al. “A Novel Dnmt3a1 Transcript Inhibits Adipogenesis.” Frontiers in Physiology (2018); 9.Read more>>
  • Abdalla et al. A Novel Dnmt3a1 Transcript Inhibits Adipogenesis. (2018) Front.Physiol. 9:1270Read more>>
  • Yang K et al. MicroRNA‐222‐3p participates in the development of oral squamous cell carcinoma by targeting CDKN1B. J Oral Pathol Med. 2019 Dec 16.Read more>>
  • Liu A et al. Down-regulation of NTSR3 inhibits growth, metastasis, and PI3K/AKT and MAPK signaling pathways in colorectal cancer cells. Biochem Cell Biol. 2020 Mar 3.Read more>>
  • Ali B et al. Control of preadipocyte proliferation, apoptosis and early adipogenesis by the forkhead transcription factor FoxO6Life Sci.2021 Jan 15;265:118858.Read more>>
  • Cuifang Chang. et al. The orphan GPR50 receptor interacting with T_RI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells. BIOCHEM PHARMACOL. 2022 Aug;202:115117Read more>>
  • Wang Haining. et al. Integrative analysis identifies oxidative stress biomarkers in non-alcoholic fatty liver disease via machine learning and weighted gene co-expression network analysis. FRONT IMMUNOL. 2024 Feb;15Read more>>
VALIDATION IMAGES