bs-0723R-HRP [Conjugated Primary Antibody]
p63 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: p63

Immunogen Range: 361-450/680


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8626

Swiss Prot: Q9H3D4

Source: KLH conjugated synthetic peptide derived from human p63 protein

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 77


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yang, Rong-Hua, et al. "An improved method for the isolation and culture of rat epidermal stem cells." International Journal of Clinical and?Experimental Pathology6.11 (2013): 2529-2534.Read more>>
  • Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, et al. (2016) Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. PLoS Pathogen 12(6): e1005544.Read more>>
  • Jianmin Li. et al. miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelialCmesenchymal transition of airway epithelial cells. Lab Invest. 2020 Sep;101(2):142-154Read more>>
  • Jian Liu. et al. Involvement of miRNA203 in the proliferation of epidermal stem cells during the process of DM chronic wound healing through Wnt signal pathways. Stem Cell Res Ther. 2020 Dec;11(1):1-1Read more>>
  • TingLu Ye. et al. 5-aminolevulinic acid photodynamic therapy inhibits invasion and metastasis of SCL-1 cells probably via MTSS1 and p63 gene related pathways. Photodiagn Photodyn. 2020 Dec;32:102039Read more>>
  • olun Cheng. et al. Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease. Bone. 2021 Sep;150:115997Read more>>
  • Amit Mittal. et al. Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. Sci Rep-Uk. 2021 May;11(1):1-11Read more>>
  • Shian Liao. et al. Construction of autophagy prognostic signature and analysis of prospective molecular mechanisms in skin cutaneous melanoma patients. Medicine. 2021 Jun 4; 100(22): e26219Read more>>
  • Rosario Garca-Rocha. et al. Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF- production. CELL BIOCHEM FUNCT. 2022 SepRead more>>
VALIDATION IMAGES