bs-0549R-RBITC
[Conjugated Primary Antibody]
Collagen 3 Polyclonal Antibody, RBITC Conjugated
DATASHEET
Host: Rabbit
Target Protein: Collagen 3
Specificity: This antibody is produced with an immunogen contained within the COLFI propeptide region, it will only recognize the full length Collagen III protein and not the mature form.
Immunogen Range: 1301-1400/1466
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 1281
Swiss Prot: P02461
Source: KLH conjugated synthetic peptide derived from human Collagen alpha 1(III) chain (C-terminal propeptide)
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.
Conjugation: RBITC
Excitation/ Emission: 540nm/625nm
Size: 100ul
Concentration: 1ug/ul
Applications: WB(1:300-5000)
Predicted Molecular Weight: 117
Cross Reactive Species:
Human
Mouse
Rat
Dog
Rabbit
Predicted Cross Reactive Species:
Cow
Chicken
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
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- Bai, Yongheng, et al. "Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway." Molecular Medicine Reports.Read more>>
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- Jiang, Ke, et al. "Effect of transforming growth factor-β3 on the expression of Smad3 and Smad7 in tenocytes." Molecular medicine reports 13.4 (2016): 3567-3573.Read more>>
- Velázquez, Kandy T., et al. "miR155 deficiency aggravates high‐fat diet‐induced adipose tissue fibrosis in male mice." Physiological Reports 5.18 (2017): e13412.Read more>>
- Yu, Chengyuan, et al. "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." Oncotarget 8.23 (2017): 37705.Read more>>
- Wang et al. The influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring. (2014) Biomed.Res.In. 2014:419805Read more>>
- Yang et al. Isolation and biological characterization of tendon-derived stem cells from fetal bovine. (2016) In.Vitro.Cell.Dev.Biol.Ani. 52:846-56Read more>>
- Zhao et al. Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation. (2014) BMC.Cardiovasc.Disor. 14:167Read more>>
- Su et al. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. (2014) Mol.Cance. 13:206Read more>>
- Zhang et al. Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-β1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure. (2016) Cell.Physiol.Biochem. 39:294-303Read more>>
- Shang L et al. Elevated β1-Adrenergic Receptor Autoantibody Levels Increase Atrial Fibrillation Susceptibility by Promoting Atrial Fibrosis. Frontiers in Physiology,(2020) 11.Read more>>
- Xiaoxiao Zhang. et al. Effect of Guanxin V in animal model of acute myocardial infarction. Bmc Complem Altern M. 2021 Dec;21(1):1-11Read more>>
- Hao Chen. et al. MicroRNA-124-3p affects myogenic differentiation of adipose-derived stem cells by targeting Caveolin-1 during pelvic floor dysfunction in Sprague Dawley rats. Ann Transl Med. 2021 Jan; 9(2): 161Read more>>
- Wei P. et al. Nintedanib ameliorates tracheal stenosis by activating HDAC2 and suppressing IL-8 and VEGF in rabbit.. Am J Transl Res. 2020 Aug;12(8):4739-4748Read more>>
- Chen Guanyin. et al. Hypoxia-Induced Mesenchymal Stem Cells Exhibit Stronger Tenogenic Differentiation Capacities and Promote Patellar Tendon Repair in Rabbits. Stem Cells Int. 2020;2020:8822609Read more>>
- Kai Zhao. et al. Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model. Biomed Pharmacother. 2021 Jun;138:111466Read more>>
- Zhenjie Huang. et al. Expression of histone deacetylase 2 in tracheal stenosis models and its relationship with tracheal granulation tissue proliferation. Exp Ther Med. 2021 May;21(5):1-1Read more>>
- Xiaoyan Sun. et al. Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts. Plos One. 2021 Apr;16(4):e0249977Read more>>
- Xiaoying Li. et al. Identification of YAP1 as a novel downstream effector of the FGF2/STAT3 pathway in the pathogenesis of renal tubulointerstitial fibrosis. 2021 May 16Read more>>
- Chao Sun. et al. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling. Exp Mol Med. 2021 Jun;53(6):1068-1079Read more>>
- Nan Hou. et al. Tissue-engineered esophagus: recellular esophageal extracellular matrix based on perfusion-decellularized technique and mesenchymal stem cells. Biomed Mater. 2021 AugRead more>>
- Siyu Li. et al. Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis. 2021 Sep 27Read more>>
- o Liang. et al. Guanxin V protects against ventricular remodeling after acute myocardial infarction through the interaction of TGF-1 and Vimentin. Phytomedicine. 2022 Jan;95:153866Read more>>
- Chengnan Tian. et al. CREB1 transcription-activated lncRNA PVT1 promotes cardiac fibrosis via miR-145/HCN1 axis. Int J Cardiol. 2022 JaRead more>>
- Meiqiong Wu. et al. Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway. SCI TOTAL ENVIRON. 2022 Apr;:155558Read more>>
- Shen, Zhou. et al. Bone marrow mesenchymal stem cells therapy on bilateral pelvic nerve crush-induced voiding dysfunction in rats. INT UROGYNECOL J. 2022 Apr;:1-8Read more>>
- Lijun Zhang. et al. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. INT J MED SCI. 2022; 19(5): 952964Read more>>
- Qi-Lin Lu. et al. Macrophage migration inhibitory factor takes part in the lumbar ligamentum flavum hypertrophy. MOL MED REP. 2022 Sep;26(3):1-9Read more>>
- Manabu Takahashi. et al. Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice. J BIOL CHEM. 2022 Aug;:102322Read more>>
- Xinxin Lan. et al. Xanthan gum/oil body-microgel emulsions with enhanced transdermal absorption for accelerating wound healing. INT J BIOL MACROMOL. 2022 SepRead more>>
- Helei Li. et al. Matrix Regeneration Ability In Situ Induced by a Silk Fibroin Small-Caliber Artificial Blood Vessel In Vivo. POLYMERS-BASEL. 2022 Jan;14(18):3754Read more>>
- Yu-jie Lu. et al. Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction. PHYTOTHER RES. 2022 OcRead more>>
- Elena Martnez-Sanz. et al. Study of the functional relationships between the buccinator muscle and the connective tissue of the cheek in humans. ANN ANAT. 2022 Nov;:152025Read more>>
- Peiran Cong. et al. Hydroxysafflor yellow A mitigates myocardial fibrosis induced by isoproterenol and angiotensin II. AM J TRANSL RES. 2022; 14(12): 8588C8598Read more>>
- Mi Bai. et al. LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. EMBO MOL MED. 2023 Jan 11Read more>>
- Shaoyan Li. et al. Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model. INT J NANOMED. 2023 Jan 05Read more>>
- Pasinlio?lu Burak. et al. Comparison of the Effects of Skin Microneedling with Cupping Therapy and Microneedling Alone: An Experimental Study. PLAST RECONSTR SURG. 2023 Jan;:10.1097/PRS.0000000000010134Read more>>
- Jia He. et al. CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of -catenin. BBA-MOL BASIS DIS. 2023 Apr;1869:166663Read more>>
- Xiaoliang Zhou. et al. Ursolic acid inhibits human dermal fibroblasts hyperproliferation, migration, and collagen deposition induced by TGF- via regulating the Smad2/3 pathway. GENE. 2023 May;867:147367Read more>>
- Lin Niu. et al. Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain. PHYTOTHER RES. 2023 JuRead more>>
- Yu Li. et al. Activating transcription factor 4 drives the progression of diabetic cardiac fibrosis. ESC HEART FAIL. 2023 JuRead more>>
- Shen Xianhe. et al. Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis. BMC CANCER. 2023 Dec;23(1):1-13Read more>>
- Du Yang. et al. Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis. CELL DEATH DIS. 2023 Aug;14(8):1-16Read more>>
- Seyeon Oh. et al. High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin. CELLS-BASEL. 2023 Jan;12(18):2275Read more>>
- Zhihao Yu. et al. Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by Schistosoma Japonicum Infection. Tropical Medicine and Infectious Disease. 2024 Feb;9(2):42Read more>>
- Yugo Miura. et al. Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa. TISSUE CELL. 2024 Mar;:10237Read more>>
- Jianrong Han. et al. Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota. J ENVIRON SCI-CHINA. 2024 ApRead more>>
- Dijun Li. et al. Tissue-engineered mesenchymal stem cell constructs alleviate tendinopathy by suppressing vascularization. BIOACT MATER. 2024 Jun;36:474Read more>>
- Yiyang Fan. et al. Effects and Significance of Dicliptera chinensis Polysaccharide on the Expression of Transforming Growth Factor 1/Connective Tissue Growth Factor Pathway in the Masseter and Head and Neck Skin of Rats With Radiation-Induced Fibrosis. INT DENT J. 2024 JulRead more>>
VALIDATION IMAGES