DATASHEET
Host:
Rabbit
Target Protein:
COL18A1
Immunogen Range:
1581-1680/1754
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
80781
Swiss Prot:
P39060
Source:
KLH conjugated synthetic peptide derived from human COL18A1/Endostatin
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
PRODUCT SPECIFIC PUBLICATIONS
- GAO, DAN, et al. "Effect of peritoneal dialysis on expression of vascular endothelial growth factor, basic fibroblast growth factor and endostatin of the peritoneum in peritoneal dialysis patients." Nephrology 16.8 (2011): 736-742.Read more>>
- Hu, Ming‑Ming, et al. "Clinical significance of serum and tumor tissue endostatin evaluation in operable non‑small cell lung cancer." Biomedical Reports.Read more>>
- Imoto, Keisuke, et al. "Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel."Pflügers Archiv-European Journal of Physiology (2016): 1-12.Read more>>
- Duan CY et al. Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells. Cell Mol Biol Lett. 2019 Apr 4;24:3. Read more>>
- Heng Jiang. et al. miR-9 promotes canine endothelial-like cell migration by targeting COL15A1. VET MED SCI. 2023 Dec;10(1):e1339Read more>>
- Duliurui Huang. et al. Analysis of the heterogeneity and complexity of murine extraorbital lacrimal gland via single-cell RNA sequencing. OCUL SURF. 2024 JuRead more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human kidney carcinoma labeled with Anti-Endostatin Polyclonal Antibody (bs-0547R), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining
Lane 1: Mouse Liver; Probed with Endostatin Polyclonal Antibody, Unconjugated (bs-0547R) at 1:500, overnight at 4°C followed by incubation with a conjugated secondary antibody for 60 minutes at 37°C.