DATASHEET
Host:
Rabbit
Target Protein:
5 lipoxygenase
Immunogen Range:
601-674/674
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
11689
Swiss Prot:
P48999
Source:
KLH conjugated synthetic peptide derived from mouse Arachidonate 5-lipoxygenase
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
PRODUCT SPECIFIC PUBLICATIONS
- Wang, Ruiqi, et al. "The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC Min/+ mice." Drug Discoveries & Therapeutics 8.1 (2014).Read more>>
- Liang, Guojuan, et al. "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." Behavioral and Brain Functions 11.1 (2015): 1.Read more>>
- Wang et al. Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation. (2016) Sci.Rep. 6:36543Read more>>
- Xinmiao Wang. et al. Caffeic acid attenuates irradiation-induced hematopoietic stem cell apoptosis through inhibiting mitochondrial damage. Exp Cell Res. 2021 Dec;409:112934Read more>>
- Hui Wang. et al. Effect of Chlorogenic Acid via Upregulating Resolvin D1 Inhibiting the NF-B Pathway on Chronic Restraint Stress-Induced Liver Inflammation. J AGR FOOD CHEM. 2022;70(34):1053210542Read more>>
- Dan-dan Feng. et al. MALAT1 binds to miR-188C3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia. MOL IMMUNOL. 2023 Aug;160:67Read more>>
- Yahui Dong. et al. Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid. J ETHNOPHARMACOL. 2024 Jan;319:11711Read more>>
- Tingting Li. et al. Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis. J PHARMACEUT BIOMED. 2024 Aug;245:116163Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-5 lipoxygenase/ALOX5 Polyclonal Antibody, Unconjugated (bs-0526R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Arachidonate 5-lipoxygenase Polyclonal Antibody, Unconjugated (bs-0526R) at 1:400 overnight at 4°C, DAB staining.