bs-0498R-APC [Conjugated Primary Antibody]
ADRB1 Polyclonal Antibody, APC Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: ADRB1

Immunogen Range: 181-250/477


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 153

Swiss Prot: P08588

Source: KLH conjugated synthetic peptide derived from human ADRB1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 52


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Deng, Guo-Hua, et al. "Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model." Journal of Experimental & Clinical Cancer Research 33:21 (2014).Read more>>
  • Bornholz, Beatrice, et al. "A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of β1-adrenergic receptor autoantibodies in human heart disease." Clinical Chemistry and Laboratory Medicine (CCLM).Read more>>
  • Tibenska V et al. Gradual cold acclimation induces cardioprotection without affecting beta-adrenergic receptor-mediated adenylyl cyclase signaling. J Appl Physiol (1985). 2020 Apr 1;128(4):1023-1032.Read more>>
  • Liu Z et al. Over-expression of microRNA-145 drives alterations in -adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction. Aging (Albany NY). 2020 Jun 18;12(12):11603-11622.Read more>>
  • Shi L et al. 1 adrenoceptor antibodies induce myocardial apoptosis via inhibiting PGC-1-related pathway. BMC Cardiovasc Disord. 2020 Jun 5;20(1):269.Read more>>
  • Jinyao Liuet al. Alcohol consumption combined with dietary low-carbohydrate/high-protein intake increased the left ventricular systolic dysfunction risk and lethal ventricular arrhythmia susceptibility in apolipoprotein E/low-density lipoprotein receptor double-knockout mice. Alcohol. 2020 Dec;89:63-74.Read more>>
  • Yue Wang. et al. Mirabegron Ameliorated Atherosclerosis of ApoE?/? Mice in Chronic Intermittent Hypoxia but Not in Normoxia. 2021 Jun 21Read more>>
  • Lina S. Farhoumand. et al. Blockade of ß-Adrenergic Receptors by Nebivolol Enables Tumor Control Potential for Uveal Melanoma in 3D Tumor Spheroids and 2D Cultures. INT J MOL SCI. 2023 Jan;24(6):5894Read more>>
  • Globig Anna-Maria. et al. The 1-adrenergic receptor links sympathetic nerves to T?cell exhaustion. NATURE. 2023 Sep;:1-1Read more>>
VALIDATION IMAGES