bs-0486R-PE
[Conjugated Primary Antibody]
Integrin beta 1 Polyclonal Antibody, PE Conjugated
DATASHEET
Host: Rabbit
Target Protein: Integrin beta 1
Immunogen Range: 25-100/798
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 3688
Swiss Prot: P05556
Source: KLH conjugated synthetic peptide derived from human Integrin beta 1
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Conjugation: PE
Excitation/ Emission: 496,564nm/578nm
Size: 100ul
Concentration: 1ug/ul
Applications:
WB(1:300-5000)
FCM(1:20-100)
Predicted Molecular Weight: 88
Cross Reactive Species:
Human
Mouse
Rat
Sheep
Rabbit
Others
Predicted Cross Reactive Species:
Dog
Cow
Pig
Horse
Chicken
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
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- Wang et al. Loss of calponin h1 confers anoikis resistance and tumor progression in the development of high-grade serous carcinoma originating from the fallopian tube epithelium. (2017) Oncotarget. 8:61133-61145Read more>>
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- Heng Chen. et al. Podosome formation in the murine palatal mucosae: Its proteolytic role in rete peg formation. Ann Anat. 2021 May;235:151703Read more>>
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- Laijun Liu. et al. Hierarchical Nanostructured Electrospun Membrane with Periosteum-Mimic Microenvironment for Enhanced Bone Regeneration. 2021 Aug 05Read more>>
- Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359Read more>>
- Shuying Hu. et al. Superparamagnetic coreCshell electrospun scaffolds with sustained release of IONPs facilitating in vitro and in vivo bone regeneration. J Mater Chem B. 2021 AugRead more>>
- Ge Liu. et al. Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. J Biol Chem. 2021 Aug;:101133Read more>>
- Xingyu Shen. et al. Extracellular Calcium Ion Concentration Regulates Chondrocyte Elastic Modulus and Adhesion Behavior. Int J Mol Sci. 2021 Jan;22(18):10034Read more>>
- Jiao, Yongjie. et al. Constructing Nanoscale Topology on the Surface of Microfibers Inhibits Fibroblast Fibrosis. Advanced Fiber Materials. 2022 Jun;:1-14Read more>>
- Yuan, Liwei. et al. Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt/-catenin signaling pathway. REPROD BIOL ENDOCRIN. 2022 Dec;20(1):1-13Read more>>
- Li Yuanyuan. et al. Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective. BIOMED RES INT. 2022;2022:7532434Read more>>
- Kara A. Davis. et al. Gelatin coating enhances therapeutic cell adhesion to the infarcted myocardium via ECM binding. PLOS ONE. 2022 Nov;17(11):e0277561Read more>>
- Kang Lu. et al. Micropattern Silk Fibroin Film Facilitates Tendon Repair In Vivo and Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells through the 21/FAK/PI3K/AKT Signaling Pathway In Vitro. STEM CELLS INT. 2023 Jan 13;2023:2915826Read more>>
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- Ma Caiyun. et al. In Vitro Culture and Multipotency Evaluation of Broiler Umbilical Cord Mesenchymal Stem Cells. BRAZ ARCH BIOL TECHN. 2023 Feb;66Read more>>
- Tan Rui-zhi. et al. Macrophages mediate psoriasis via Mincle-dependent mechanism in mice. CELL DEATH DISCOV. 2023 Apr;9(1):1-13Read more>>
- Yuanyuan Li. et al. Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model. J INFLAMM RES. 2023 May 24Read more>>
- Yongjie Jiao. et al. Cobweb-Inspired Micro/Nanostructured Scaffolds for Soft Tissue Regeneration with Inhibition Effect of Fibrosis under Dynamic Environment. ADV HEALTHC MATER. 2023 Sep;:2300997Read more>>
- Shanshan Wu. et al. Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia. EXP EYE RES. 2024 Apr;241:109849Read more>>
- Weiguang Zhao. et al. Biomimetic multilayer scaffolds with prolonged retention of stem cells-recruiting and angiogenic peptides for promoting bladder regeneration. COMPOSITES PART B-ENGINEERING. 2024 May;277:111409Read more>>
- Yue Wu. et al. The biological characteristics of chicken embryo mesenchymal stem cells isolated from chorioallantoic membrane. GENESIS. 2024 Apr;62(2):e23592Read more>>
- Ma Caiyun. et al. Characteristics and Multilineage Differentiation of a Novel Type of Pulmonary Mesenchymal Stem Cells Derived from Goose Embryos. BRAZ ARCH BIOL TECHN. 2024 Apr;67:e24230139Read more>>
- Hui Ke. et al. Study on the anti-skin aging effect and mechanism of Sijunzi Tang based on network pharmacology and experimental validation. J ETHNOPHARMACOL. 2024 Jun;:118421Read more>>
VALIDATION IMAGES