bs-0486R-APC
[Conjugated Primary Antibody]
Integrin beta 1 Polyclonal Antibody, APC Conjugated
DATASHEET
Host: Rabbit
Target Protein: Integrin beta 1
Immunogen Range: 25-100/798
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 3688
Swiss Prot: P05556
Source: KLH conjugated synthetic peptide derived from human Integrin beta 1
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Conjugation: APC
Excitation/ Emission: 650nm/660nm
Size: 100ul
Concentration: 1ug/ul
Applications:
WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
Predicted Molecular Weight: 88
Cross Reactive Species:
Human
Mouse
Rat
Sheep
Rabbit
Others
Predicted Cross Reactive Species:
Dog
Cow
Pig
Horse
Chicken
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
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- Jiang, Xiaorong, et al. "The role of CD29-ILK-Akt signaling-mediated epithelial–mesenchymal transition of liver epithelial cells and chemoresistance and radioresistance in hepatocellular carcinoma cells." Medical Oncology 32.5 (2015): 1-8.Read more>>
- Deng, Wei, et al. "Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis." International Journal of Clinical and Experimental Pathology 8.9 (2015): 10555-10564.Read more>>
- Qin, Jie, et al. "Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway." International Journal of Molecular Medicine.Read more>>
- Wang, Yan, et al. "Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-β1 signaling pathway." BMC Complementary and Alternative Medicine 16.1 (2016): 319.Read more>>
- Oralova, V., et al. "Osteogenic Potential of the Transcription Factor c-MYB." Calcified Tissue International: 1-12.Read more>>
- Zhan, Fu‐Liang, Xin‐Yang Liu, and Xing‐Bo Wang. "The Role of MicroRNA‐143‐5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." Journal of Cellular Biochemistry (2017).Read more>>
- Fu, Min, et al. "Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice." Nutrients 8.5 (2016): 286.Read more>>
- Zhao, Xue, et al. "Knockdown of Snail inhibits epithelial-mesenchymal transition of human laryngeal squamous cell carcinoma Hep-2 cells through VDR signaling pathway." Biochemistry and Cell Biology ja (2017).Read more>>
- Ji, Kaiyuan, et al. "MicroRNA 143‐5p regulates alpaca melanocyte migration, proliferation, and melanogenesis." Experimental dermatology (2017).Read more>>
- Wang et al. Loss of calponin h1 confers anoikis resistance and tumor progression in the development of high-grade serous carcinoma originating from the fallopian tube epithelium. (2017) Oncotarget. 8:61133-61145Read more>>
- Zhan et al. The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway. (2018) J.Cell.Biochem. 119:536-546Read more>>
- Lu T et al. In vitro culture and biological properties of broiler adipose‑derived stem cells.Exp Ther Med. 2018 Sep;16(3):2399-2407.Read more>>
- Gao Y et al. Induction of autophagy protects human dental pulp cells from lipopolysaccharide‑induced pyroptotic cell death. Exp Ther Med. 2020 Mar;19(3):2202-2210.Read more>>
- Heng Chen. et al. Podosome formation in the murine palatal mucosae: Its proteolytic role in rete peg formation. Ann Anat. 2021 May;235:151703Read more>>
- Ziwei Luo. et al. miR\203a\3p promotes loureirin A\induced hair follicle stem cells differentiation by targeting Smad1. Anat Rec. 2021 Mar;304(3):531-54Read more>>
- Laijun Liu. et al. Hierarchical Nanostructured Electrospun Membrane with Periosteum-Mimic Microenvironment for Enhanced Bone Regeneration. 2021 Aug 05Read more>>
- Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359Read more>>
- Shuying Hu. et al. Superparamagnetic coreCshell electrospun scaffolds with sustained release of IONPs facilitating in vitro and in vivo bone regeneration. J Mater Chem B. 2021 AugRead more>>
- Ge Liu. et al. Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. J Biol Chem. 2021 Aug;:101133Read more>>
- Xingyu Shen. et al. Extracellular Calcium Ion Concentration Regulates Chondrocyte Elastic Modulus and Adhesion Behavior. Int J Mol Sci. 2021 Jan;22(18):10034Read more>>
- Jiao, Yongjie. et al. Constructing Nanoscale Topology on the Surface of Microfibers Inhibits Fibroblast Fibrosis. Advanced Fiber Materials. 2022 Jun;:1-14Read more>>
- Yuan, Liwei. et al. Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt/-catenin signaling pathway. REPROD BIOL ENDOCRIN. 2022 Dec;20(1):1-13Read more>>
- Li Yuanyuan. et al. Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective. BIOMED RES INT. 2022;2022:7532434Read more>>
- Kara A. Davis. et al. Gelatin coating enhances therapeutic cell adhesion to the infarcted myocardium via ECM binding. PLOS ONE. 2022 Nov;17(11):e0277561Read more>>
- Kang Lu. et al. Micropattern Silk Fibroin Film Facilitates Tendon Repair In Vivo and Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells through the 21/FAK/PI3K/AKT Signaling Pathway In Vitro. STEM CELLS INT. 2023 Jan 13;2023:2915826Read more>>
- Lu, Kang. et al. N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin 5/1/PI3K/AKT signaling. BMC MOL CELL BIOL. 2023 Dec;24(1):1-13Read more>>
- Ma Caiyun. et al. In Vitro Culture and Multipotency Evaluation of Broiler Umbilical Cord Mesenchymal Stem Cells. BRAZ ARCH BIOL TECHN. 2023 Feb;66Read more>>
- Tan Rui-zhi. et al. Macrophages mediate psoriasis via Mincle-dependent mechanism in mice. CELL DEATH DISCOV. 2023 Apr;9(1):1-13Read more>>
- Yuanyuan Li. et al. Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model. J INFLAMM RES. 2023 May 24Read more>>
- Yongjie Jiao. et al. Cobweb-Inspired Micro/Nanostructured Scaffolds for Soft Tissue Regeneration with Inhibition Effect of Fibrosis under Dynamic Environment. ADV HEALTHC MATER. 2023 Sep;:2300997Read more>>
- Shanshan Wu. et al. Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia. EXP EYE RES. 2024 Apr;241:109849Read more>>
- Weiguang Zhao. et al. Biomimetic multilayer scaffolds with prolonged retention of stem cells-recruiting and angiogenic peptides for promoting bladder regeneration. COMPOSITES PART B-ENGINEERING. 2024 May;277:111409Read more>>
- Yue Wu. et al. The biological characteristics of chicken embryo mesenchymal stem cells isolated from chorioallantoic membrane. GENESIS. 2024 Apr;62(2):e23592Read more>>
- Ma Caiyun. et al. Characteristics and Multilineage Differentiation of a Novel Type of Pulmonary Mesenchymal Stem Cells Derived from Goose Embryos. BRAZ ARCH BIOL TECHN. 2024 Apr;67:e24230139Read more>>
- Hui Ke. et al. Study on the anti-skin aging effect and mechanism of Sijunzi Tang based on network pharmacology and experimental validation. J ETHNOPHARMACOL. 2024 Jun;:118421Read more>>
VALIDATION IMAGES