DATASHEET
Host:
Rabbit
Target Protein:
TSHR
Immunogen Range:
501-600/764
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
7253
Swiss Prot:
P16473
Source:
KLH conjugated synthetic peptide derived from human TSHR
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
PRODUCT SPECIFIC PUBLICATIONS
- Wang ML et al. MALAT1 rs619586 polymorphism functions as a prognostic biomarker in the management of differentiated thyroid carcinoma. J Cell Physiol. 2019 Aug 27. Read more>>
- Dong X et al. PM2.5 disrupts thyroid hormone homeostasis through activation of the hypothalamic-pituitary-thyroid (HPT) axis and induction of hepatic transthyretin in female rats 2.5Ecotoxicol Environ Saf.2021 Jan 15;208:111720.Read more>>
- Shivangi Agarwal. et al. Deiodinase-3 is a thyrostat to regulate podocyte homeostasis. Ebiomedicine. 2021 Oct;72:103617Read more>>
- Dong, Xinwen. et al. Protective effects of curcumin against thyroid hormone imbalance after gas explosion-induced traumatic brain injury via activation of the hypothalamic-pituitary-thyroid axis in male rats. ENVIRON SCI POLLUT R. 2022 May;:1-13Read more>>
VALIDATION IMAGES
Mouse thymocytes probed with Rabbit Anti-TSHR Polyclonal Antibody, Unconjugated (bs-0460R) (green) at 1:100 for 60 minutes followed by a FITC conjugated secondary compared to control cells (blue).
Formalin-fixed and paraffin embedded mouse spleen labeled with Rabbit Anti-TSHR Polyclonal Antibody (bs-0460R)at 1:200 followed by conjugation to the secondary antibody and DAB staining