bs-0439R-PerCP [Conjugated Primary Antibody]
ACE Polyclonal Antibody, PerCP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: ACE

Immunogen Range: 801-900/1306


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1636

Swiss Prot: P12821

Source: KLH conjugated synthetic peptide derived from Human ACE1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Angiotensin Converting enzyme is involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.

Conjugation: PerCP

Excitation/ Emission: 482nm/677nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 147


Cross Reactive Species: Human
Mouse
Rat
Dog

Predicted Cross Reactive Species: Cow
Sheep
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192.Read more>>
  • "Jiang, Yichuan, et al. ""Ginsenoside Rg3 induces ginsenoside Rb1-comparable cardioprotective effects independent of reducing blood pressure in spontaneously hypertensive rats."" Experimental and Therapeutic Medicine. "Read more>>
  • Jiang et al. Ginsenoside Rg3 induces ginsenoside Rb1-comparable cardioprotective effects independent of reducing blood pressure in spontaneously hypertensive rats. (2017) Exp.Ther.Med. 14:4977-4985Read more>>
  • Zhang et al. Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer. (2017) Cancer.Biol.Ther. 18:606-615Read more>>
  • Deng T et al. Di-(2-ethylhexyl) phthalate induced an increase in blood pressure via activation of ACE and inhibition of the bradykinin-NO pathway. Environ Pollut. 2019 Apr;247:927-934. Read more>>
  • Deng T et al. Exposure to diisononyl phthalate induced an increase in blood pressure through activation of the ACE/ AT1R axis and inhibition of NO production. Toxicol Lett. 2019 Jul;309:42-50.Read more>>
  • Xie X et al. Comparing the effects of diethylhexyl phthalate and dibutyl phthalate exposure on hypertension in mice.Ecotoxicol Environ Saf. 2019 Jun 15;174:75-82.Read more>>
  • Liu H et al. Ginsenoside Rg3 Attenuates Angiotensin II-Mediated Renal Injury in Rats and Mice by Upregulating Angiotensin-Converting Enzyme 2 in the Renal Tissue. Evid Based Complement Alternat Med. 2019 Nov 29;2019:6741057.Read more>>
  • Chen ZZ et al. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2019 Nov 20;240:117085.Read more>>
  • Ademola Adetokunbo Oyagbemi et al. Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway. Eur J Pharmacol. 2020 Aug 5;880:173142.Read more>>
  • Xiaohua Liang . et al. Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension. Clin Exp Hypertens. 2021;43(2):151-163Read more>>
  • Peng Wang. et al. ASSOCIATION ANALYSIS AND EXPRESSION LEVEL OF ACE POLYMORPHISMS WITH EGG-LAYING TRAIT IN TAIHANG CHICKEN. POULTRY SCIENCE. 2022 Sep;:102163Read more>>
  • Shuwei Wang. et al. Formaldehyde causes an increase in blood pressure by activating ACE/AT1R axis. TOXICOLOGY. 2023 Mar;486:153442Read more>>
  • Cong Changsheng. et al. Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1C7) axis via NF-B/MAPK pathway. SCI REP-UK. 2023 May;13(1):1-11Read more>>
VALIDATION IMAGES