bs-0252R-PE [Conjugated Primary Antibody]
Glucocorticoid receptor Antibody, PE Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Glucocorticoid receptor

Immunogen Range: 231-320/777


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2908

Swiss Prot: P04150

Source: KLH conjugated synthetic peptide derived from human Glucocorticoid receptor

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 85


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Takigawa, Toshimichi, et al. "Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology (2013).Read more>>
  • Guo et al. Androgen receptor reverts dexamethasone?induced inhibition of prostate cancer cell proliferation and migration. (2018) Mol.Med.Rep. 17:5887-5893Read more>>
  • Pang et al. Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris. (2015) Exp.Ther.Med. 10:419-422Read more>>
  • Zoratto, F. et al.Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness. (2018) Neuropharmacology.Sep 10;143:250-267. Read more>>
  • Daneng Wei. et al. The Volatile Oil of <em>Zanthoxylum bungeanum</em> Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats. Drug Des Dev Ther. 2021 Feb;15:769-786Read more>>
  • Ting-Wang Xiong. et al. Beneficial effects of Dendrobium nobile Lindl. Alkaloids (DNLA) on anxiety and depression induced by chronic unpredictable stress in rats. Brain Res. 2021 Nov;1771:147647Read more>>
VALIDATION IMAGES