bs-0173R-BF405 [Conjugated Primary Antibody]
IRS-2 Polyclonal Antibody, AbBy Fluor® 405 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
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DATASHEET

Host: Rabbit

Target Protein: IRS-2

Immunogen Range: 501-600/1324


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8660

Swiss Prot: Q9Y4H2

Source: KLH conjugated synthetic peptide derived from human IRS-2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The family of insulin receptor substrates (IRSs) has been reported to play important roles for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however, the distinct physiological roles of each IRS are unclear. Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Conjugation: AbBy Fluor® 405

Excitation/ Emission: 401nm/421nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 146


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Ling, Qi, et al. "Donor graft microRNAs: a newly identified player in the development of new‐onset diabetes after liver transplantation." American Journal of Transplantation (2016).Read more>>
  • Wang, Fan, et al. "Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome." Molecular Medicine Reports (2017).Read more>>
  • Wang H et al. MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2 J Bone Oncol. 2019 May 11;17:100241. Read more>>
  • Ningfei Ji. et al. SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients. 2022 Mar 28Read more>>
  • Ye Xiang. et al. Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse. NUTR DIABETES. 2024 Mar;14(1):1-8Read more>>