bs-0088R [Primary Antibody]
Secretin Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Secretin

Immunogen Range: 28-54/121


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6343

Source: KLH conjugated synthetic peptide derived from human Secretin

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(WB=1:500-2000)
ELISA(ELISA=1:5000-10000)
IHC-P(IHC-P=1:100-500)
IHC-F(IHC-F=1:100-500)
IF(IF=1:100-500)

Predicted Molecular Weight: 3


Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhang et al. The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning. (2014) Neuropsychopharmacolog. 39:1460-8Read more>>
  • Lixian Chen. et al. Inhibition of secretin/secretin receptor axis ameliorates non\alcoholic fatty liver disease phenotypes. 2021 Apr 3Read more>>
  • Yildiz, M.. et al. The Effect of Chronic Intermittent Cold Exposure on Gastrin-, Somatostatin-, Secretin-, and Serotonin-Containing Cells in the Small Intestine of Rats. Biol Bull+. 2021 Dec;48(3):S95-S106Read more>>
  • Lamei Xue. et al. Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring. EMBO REP. 2022 Jul;23(7):e54132Read more>>
  • Yuchu ?Liu. et al. A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit. SCI ADV. 2023 Feb;9(7)Read more>>
VALIDATION IMAGES

Lane 1: Human SW480 cell lysates; Lane 2: Human MCF-7 cell lysates; Lane 3: Human HepG2 cell lysates probed with Secretin Polyclonal Antibody, Unconjugated (bs-0088R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.