DATASHEET
Host:
Mouse
Target Protein:
CREB-1
Immunogen Range:
101-150/341
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
1385
Swiss Prot:
P16220
Source:
KLH conjugated synthetic peptide derived from human CREB-1
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
PRODUCT SPECIFIC PUBLICATIONS
- Liang Shi-peng. et al. Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10. ACTA PHARMACOL SIN. 2023 Jun;:1-14Read more>>
- Huifang Niu. et al. Molecular Mechanism of Pasteurized Akkermansia muciniphila in Alleviating Type 2 Diabetes Symptoms. J AGR FOOD CHEM. 2024;72(23):1308313098Read more>>
- Lan Yan-Ping. et al. Analysis of the functional role and mRNA expression of GABABR in the nucleus accumbens of cocaine-addicted rats. J CHIN MED ASSOC. 2024 Jun;:10.1097/JCMA.0000000000001119Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human endometrium labeled with Anti-CREB-1 Polyclonal Antibody, Unconjugated (bs-0035M) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Lane 1: Mouse Kidney lysates; Lane 2: Rat Kidney lysates; Lane 3: Mouse Testis lysates; Lane 4: Rat Testis lysates; Lane 5: Mouse Liver lysates probed with CREB-1 Polyclonal Antibody, Unconjugated (bs-0035M)at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.